The LC-4000 Series is the latest in a long history of innovative HPLC systems developed by JASCO, reaching all the way back to the start of commercial HPLC in the early 1970s. The concept of the integrated LC-4000 series HPLC provides key separation platforms at 50MPa, 70MPa, and 130MPa which correspond to conventional HPLC, the increasingly popular Rapid Analysis (RHPLC), and sub 2um UHPLC respectively.
For nearly three decades JASCO analytical HPLC pumps have employed an asymmetric twin-piston solvent delivery system SSQD (Slow Suction, Quick Delivery) which provides significantly better flow and pressure profiles than other conventional twin-piston reciprocating designs. In the LC-4000 Series, SSQD has been re-developed, with a completely new solvent delivery mechanism ExReFT (Extremely Reliable Flow Technology) offering the highest stability in solvent delivery across the entire analytical flow rate range used in the PU-4180/85 RHPLC and PU-4280/85 UHPLC pump models.
As a pioneer in optical spectroscopy, JASCO has access to optical designs that few can match. Taking advantage of our more powerful spectrometers, we have developed a range of HPLC detectors with unrivaled performance, like the new class leading FP-4020 fluorescence detector ( water Raman S/N > 2300:1, the latest high-speed refractive index detector with micro cell optimized for UHPLC and the unique circular dichroism detector for chiral chromatography.
With the range of column technologies becoming increasingly diverse – the traditional 5μm fully porous particle is finally losing ground to some of the newer technologies such as the new superficially porous solid core (Coreshell) and the wide variety of sub-2μm particles – the requirements for method development are becoming more demanding. Designed to accommodate analytical, preparative and multiple columns at every scale with options for integrated 6 or 10 solvent and column selection valves. The LC-4000 Series has a number of newly developed accessories to make better separations faster.
Despite the extra power delivered by the LC-4000 Series HPLC, the standard footprint is only 300 mm wide – a standard system requires only a very small amount of bench space. For easy maintenance, all LC-4000 instruments feature front-panel access for replacing consumables such as pump components and light sources. The autosampler consumables such as the syringe parts are easy to access. For users requiring front-panel control, the LC-4000 Series retains a keypad and backlit LED display. Keypad control can still be configured for convenient override when under PC control.
Front-panel access to light source and consumables
Each LC-4000 module is designed for easy maintenance. The LC-4000 Series pump module requires smaller bench space than ordinary HPLC pumps. An integrated solvent delivery system can be incorporated into a single pump module.
The LC-4000 Series 70 MPa system has been designed to future-proof your HPLC requirements. The LC-4000 70 MPa system can be used with conventional 3 and 5 μm particle size analytical columns at typical lower pressures around 10 to 20 MPa (1500 to 3000 psi) and can also be used with smaller particles such as shorter length UHPLC columns and superficially porous (SPP) or Coreshell that require slightly higher pressure solvent delivery to provide optimum linear velocity through the column.
Ten years after the new segment of the HPLC market, UHPLC has found a niche for those that need to run a large number of samplers or get results quickly. Pioneering column technology is pushing the particle size even smaller. The near 20,000 psi operation of the LC-4000 130 MPa is designed to take advantage of the separation efficiency of the very small particles couple with longer and narrower columns. The LC-4000 130 MPa system incorporates many of the same features as the 70 MPa system, but with materials designed to withstand higher pressures.
The LC-4000 preparative HPLC systems includes three platform options:
Large column oven for multiple preparative columns and optional automatic column switching
Open-bed fraction collector with sample trays for tubes, plates or large containers
ChromNAV-FC for fraction control using time, threshold or slope from up to 4 different signals
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