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CD Reference





Dichroweb for Protein Secondary Structure Determinations

Protein Circular Dichroism Data Base

NPL Reference Source for Optical Spectroscopy used in Biological Molecule analysis

Molecular Light Scattering and Optical Activity, Second Edition

Circular Dichroism - Spectroscopy











Laurence D. BarronPublished September 2004
Cambridge University Press
466 pages, 79 line diagrams
ISBN: 0521813417 Hardback

Using classical and quantum methods with a strong emphasis on symmetry principles, this book develops the theory of a variety of optical activity and related phenomena from the perspective of the molecular scattering of polarized light. In addition to the traditional topic of optical rotation and circular dichroism in the visible and ultraviolet regions associated with electronic transitions, the newer topic of optical activity associated with vibrational transitions, which may be studied using both infrared and Raman techniques, is also treated. Ranging from the physics of elementary particles to the structure of viruses, the book reflects the importance of optical activity and chirality in much of modern science and will be of interest to a wide range of physical and life scientists.


Preface to the first edition; Preface to the second edition; 1. A historical review of optical activity phenomena; 2. Molecules in electric and magnetic fields; 3. Molecular scattering of polarized light; 4. Symmetry and optical activity; 5. Natural electronic optical activity; 6. Magnetic electronic optical activity; 7. Natural vibrational optical activity; 8. Antisymmetric scattering and magnetic Raman optical activity; References; Index

The four years since the publication of the first edition of Circular Dichroism - Principles and Applications have seen a rapid expansion of the field, including new applications, improved understanding of principles, and a growing interest in circular Dichroism (CD) among researchers from a wide variety of disciplines. The Second Edition keeps pace with this phenomenal growth with up-to-date contributions from dozens of the world's leading researchers and practitioners in chirality, chemistry, biochemistry, and analytical chemistry, as well as vibrational and luminescence spectroscopy. 

With nine entirely new chapters and substantial updates of existing material, Circular Dichroism, Second Edition provides important insight into the immense potential of CD and bridges the gap between theory and practice. The book begins with coverage of historical developments and moves quickly to fascinating reports on recent advances and emerging new fields  in CD. New and updated coverage includes:  




Multidisciplinary Coverage of Circular Dichroism's Principles, Applications and Latest Advances

  • VOA theory
  • Solid-state CD applications
  • Fast time-resolved CD measurements
  • A model illustrating how polymers amplify chirality
  • Induced CD of polymers
  • CD of nucleic acids: nonclassical conformations and modified oligonucleotides
  • DNA-drug and DNA-protein interactions
  • Applications of CD to important pharmaceutical compounds

Circular Dichroism - Spectroscopy

Featuring an increased emphasis on biological molecules and extensive applications to organic stereochemistry and biopolymers, Circular Dichroism: Principles and Applications, Second Edition will prove a valuable and frequently consulted reference for organic chemists, biochemists, and medicinal and pharmaceutical chemists. 

ISBN 0-471-33003-5 Wiley-VCH

This is the first title in the new Oxford Chemistry Masters Series. These books are designed to provide clear and concise accounts of important topics both established and emergent that may he encountered by chemistry students as they progress from the senior undergraduate stage through post-graduate study to leadership in research. These Masters assume little prior knowledge, other than the foundations provided by an undergraduate degree in chemistry and lead the reader through to an appreciation of the state-of-the-art in the topic whilst providing an entre to the original literature in the field.

Circular Dichroism - Spectroscopy


Circular Dichroism and linear Dichroism provides an introduction to all those wishing lo use the complementary spectroscopic techniques of optical activity (Circular Dichroism, CD) and optical anisotropy (Linear Dichroism, LD) for the study of the structure of molecules and interactions between molecules in solution. The emphasis of the book is on the techniques involved and how to use them for both low and high molecular weight molecules. It is an easy guide to what the prospective user of CD needs to know and explains how LD is not merely an exotic technique only to be practiced by experienced spectroscopists, but may he routinely and usefully employed as an aid to molecular structure determination.

The book begins by describing the principles behind CD and LD and how these techniques can be used in the laboratory without using advanced mathematics or quantum mechanics. The next chapters describe how both techniques may be applied to the study of biological macromolecules and give a detailed description of how they may be used on small molecules to investigate molecular and electronic structure. The last part contains theoretical derivations of all the equations required for the applications described previously. Throughout the book specific molecular examples are used to illustrate concepts and to show the reader how to use the techniques in chemical and biological systems. 

Circular Dichroism and linear Dichroism is an easily understandable and directly applicable manual to the use and interpretation of both CD and LD. It will be of use to both novices and experienced researchers in the field.

Alison Rodger is Lecturer in Biological and Medicinal Chemistry in the Department of Chemistry at the University of Warwick.

Bengt Nord'n is Professor of Physical Chemistry at Chalmers University of Technology Gothenburg.

ISBN 0-19-855897-X Oxford University Press